Motorists are being asked to approach Ballylickey, near Bantry, with caution following a serious road traffic collision involving a lorry and a car.
Gardaí are on site, dealing with the emergency, in which two people were injured. The road is now closed to passing traffic, but diversions are in place.
Bantry Fire Brigade, assisted by Skibbereen Fire Brigade, are at the scene, and the National Ambulance Service are also in attendance.
Gardai confirmed that the casualties have been taken to hospital.
No further details relating to the collision have been released because the incident only occurred at about 4.30pm today.